Senate Republicans will hold a Thursday vote on a GOP proposal aimed at lowering health insurance premiums, even as deep disagreements roil the party. With two influential committee chairs helping craft the plan, leaders hope to tamp down rising premiums—but skeptics within the conference are voicing strong reservations.

Senate Republicans are moving to end a seven-month obstruction of President Trump’s nominees. John Thune, at the forefront of these efforts, plans to use the so-called “nuclear option” to break Chuck Schumer’s blockade and secure long-delayed confirmations.