The San Francisco 49ers fear that their promising first-round pick, Mykel Williams, has suffered a devastating ACL tear. As the team grapples with numerous injuries already, fans wonder how long the 49ers can endure this relentless war of attrition.

Kyler Murray’s injury troubles persist, forcing the Arizona Cardinals to name Jacoby Brissett as the starting quarterback for Monday Night Football. Head coach Jonathan Gannon had expected Murray to return, but announced his continued absence ahead of the team’s game against the Dallas Cowboys.

Two key players—Malik Nabers of the New York Giants and Joe Alt of the Los Angeles Chargers—have both received discouraging injury updates. According to the original report, neither star got the good news their teams had hoped for, potentially impacting upcoming matchups.

Philadelphia’s latest injury report brings both concern and uncertainty. Zack Baun and Jihaad Campbell are sitting out, while Lane Johnson is limited.

Week 2 of the 2025 NFL season brought a fresh crop of injuries to the forefront, with Joe Burrow and Jayden Daniels among those affected. Their updated statuses could reshape fantasy football lineups in the coming weeks.

The Minnesota Vikings will head into Sunday night’s matchup against the Atlanta Falcons without three pivotal defensive players, including standout safety Harrison Smith. Their absence raises questions about the team’s defensive depth and their strategy to contain Atlanta’s offense.

The Los Angeles Rams’ first-half showdown against the Houston Texans was marked by a wave of injuries, including another offensive lineman going down. Multiple Rams players remained questionable to return, raising urgent concerns about the team’s depth and resilience right out of the gate.

Carolina Panthers linebacker DJ Johnson will miss Sunday’s game after suffering a concussion in a car accident. Johnson has been placed on the non-football injury list as the team prepares to face the Atlanta Falcons.