In this seasonal edition of “Dear Annie,” readers are presented with an advisory perspective on how to approach family get-togethers with grace. The column also extends warm holiday wishes, underscoring the significance of kindness and goodwill during the festive season.

A longstanding question about testosterone replacement therapy (TRT) resurfaces: does it heighten the risk of heart attacks? According to one reader’s understanding of a large-scale study, men on TRT did not show increased cardiovascular risk, offering points to ponder in this ongoing discussion.

One reader wonders how a Christmas celebration can become so fraught with tension. As she confides in “Dear Annie,” she shares the stress that builds before dinner, leaving her on edge as soon as everyone sits down at the table.

As one family prepares for a baby’s arrival, a grieving father struggles with his new stepmother’s claim on the “grandma” title—raising questions about honoring a lost loved one’s memory. The result is a poignant look at how grief, love, and tradition intersect in modern family dynamics.

A new article highlights Orforglipron, Cagrilintide, and the Libre Assist as potential breakthroughs in diabetes management, though the complete details remain behind a paywall. Published by Hcplive, the piece underscores the continued push toward innovative therapies and technologies for people living with diabetes.

Some cancer cells dodge immune attacks by staying on the move, preventing complete engulfment. Instead, the body’s defensive cells manage only to nibble at the edges. Scientists are observing how this behavior might shape the future of cancer research and treatment.

A new therapy called Vixarelimab has shown rapid, sustained clinical benefits in prurigo nodularis. Although most details remain behind paid content, this announcement highlights potentially encouraging news for those affected by this skin condition.

Migraines can sometimes be triggered by strong fragrances, making perfume-free living a welcome relief for many. In her latest column, Heloise also shares practical ideas on storing canned goods and more everyday tips.

A concerned daughter-in-law questions how to handle her mother-in-law’s request to move in. With health issues looming, she wonders how to offer help while still maintaining healthy boundaries.

A mother-in-law’s request for her adult children to move in and “take care of her and the house” raises pressing questions about the boundaries of familial duty. The story highlights a universal dilemma: how much should family members be expected to do?

A Duluth teenager and her mother are candidly charting their mental health journey through a shared podcast. Funded by the Ann Bancroft Foundation, their project aims to destigmatize emotional challenges and inspire others to speak openly.

Orthopedic care is poised for growth in the Quad-Cities, fueled by an aging population and an enduring passion for an active lifestyle. Local healthcare providers predict that demand for specialized services will surge in the coming years, aiming to keep residents stronger and mobile longer.

For some individuals with Alzheimer’s disease, music strikes a chord when other forms of communication fail. A reader’s question to medical professionals explores how familiar songs and melodies might not only trigger memories but also protect cognitive abilities.

Two death doulas in Gallatin County, Montana, are reshaping how families experience the end of life. By providing a compassionate presence and stress-free support, they work alongside hospice services to help people face their final days with dignity.

Imviva Biotech has revealed promising new data for its allogeneic CAR-T cell therapies, CTD402 and CTA311, at the 67th American Society of Hematology Annual Meeting. Early clinical findings suggest significant progress toward treating T-cell and B-cell malignancies, as well as severe aplastic anemia, through innovative approaches that may offer enhanced efficacy and widened patient access.

In this “Asking Eric” column, R. Eric Thomas addresses a reader who can’t stop thinking about their former spouse, who once admitted cheating. The piece explores how a painful marital past can linger long after both partners have moved on.

According to neurologist Dr. Joel Salinas, small changes repeated over time can significantly boost brain health, particularly for those feeling lonely during the holidays. His advice highlights the importance of lifestyle consistency and the potential for slowing cognitive decline.

Nanjing Leads Biolabs Co., Ltd. presented new clinical data on LBL-034 at the 67th Annual Meeting of the American Society of Hematology (ASH) in Orlando. The results, featuring a median progression-free survival (PFS) trending beyond one year, spotlight a potential breakthrough in hematology.

A rush of energy and excitement can seem thrilling—until the financial and emotional costs of mania come into view. Whether overspending or overcommitting schedules, this heightened state often leads to a sobering reality check.

A new gemcitabine intravesical system appears to lower the likelihood of radical cystectomy in high-risk, BCG-unresponsive non–muscle invasive bladder cancer. Published on Onclive, the article highlights how this therapy could significantly impact patient care moving forward.

BioAge Labs, Inc. has released interim results showing that its novel brain-penetrant NLRP3 inhibitor, BGE-102, was well-tolerated in early testing. Preliminary data suggests this once-daily oral medication could bring new options for conditions linked to inflammatory pathways.